King Of Medicinal Fungus

Found only in Taiwan, Cinnamomum Camphora is a thick solid tree that blossoms sticky flowers to attract insects. It is difficult for the parent tree to pollinate because the flowers are located high up in the tree, exposed to strong winds. Furthermore, the seeds are ravaged by birds and animals before they even mature, making seed collection difficult. In the natural state, there are few natural renewal clusters. Cinnamomum Camphora germination rarely occurs due to thick undergrowth, and even if seeding takes place, seedlings seldom survive due to inadequate sunlight.

There is a wide variety of Cinnamomum Camphora. We had to visit the original habitat of Cinnamomum Camphora and gather the seedlings at the base of parent trees and culture them. Cinnamomum Camphora have strict demands on their growing environment, preferring fertile well-drained soil that is moderately moist, with very little rocks but a lot of humus (rotting matters). Fortunately, they propagate quickly at the initial stages.

Since Cinnamomum Camphora cultivation is difficult, we started studying asexual farming 10 years ago and perfected the most important part of the breeding process. Cinnamomum Camphora seedlings are strong, and their sprouts and roots exhibit the strongest germinating power, with a rooting rate of 10%-15%, but still too low to reach our production requirement. As such, the first-generation seedlings are carefully cultivated in a special nursery, and their seeds are cultured to achieve a rooting rate of 70% and above. Moreover, these seeds can be cultured widely in tunnel greenhouses or greenhouses with automatic and intermittent spray systems. Presently there are over 10 kinds of techniques in Cinnamomum Camphora culturing. 

Deity Mushroom, A Medicinal Fungus

Antrodia Cinnamomea is known as Deity Mushroom or King of Medicinal Fungus, amongst various other names. It is essentially a species of medicinal fungus that is found only in Taiwan. It is called Yin and Yang Mushroom in local folklores. The beneficial properties of Antrodia Cinnamomea are well-known among Taiwanese aborigines, who regard wild Antrodia as an esoteric panacea because of numerous beneficial testimonials. The host for Antrodia Cinnamomea is the Cinnamomum Camphora which is native only to Taiwan, growing on hilly terrains 450-2000 metres above sea level from June to October. 

Due to a high demand for carvings, furniture and camphor oil, Cinnamomum Camphora are nearly extinct due to indiscriminate felling. For this reason, Cinnamomum Camphora have been given the highest conservation status—a national treasure.

Besides the basswood technique, liquid and solid culturing are also used by biotechnology companies to cultivate Antrodia Cinnamomea, the last two techniques of which are employed to produce value-for-money health food supplements since they do not involve felling trees.

Main Features

Antrodia Cinnamomea is teeming with 200 over types of bioactive ingredients, including triterpenoids, polysaccharides, SOD, adenosine etc. Numerous clinical trials have proven that the higher the content of bioactive ingredients, the more marked the anti-cancer, liver protection and cardiovascular protection properties of the Cinnamomea.

Polysaccharides: A ‘solid body’ of Antrodia Cinnamomea contains 2% polysaccharides, as in any other medicinal mushrooms. They show immuno-physiological actions to prevent tumour growth. The main group of polysaccharides–β-glucans—activate macrophages, T-lymphocytes, B-lymphocytes as well as natural killer cells to curb tumours by boosting the body’s immunity. Antrodia polysaccharides can also strengthen the heart; lower blood pressure, blood glucose etc.

Triterpenoids: They can suppress tumour growth, kill leukaemia cells in mice, inhibit parasympathetic functions, stimulate neuron growth etc. They play a more vital role than polysaccharides in anti-cancer actions. At the same time, they can effectively suppress Angiotensin Converting Enzyme (ACE) action to lower blood pressure.

SOD: This is the primary enzyme that eradicates reactive oxygen species in the body, controlling pathogenesis due to free radicals. It effectively removes free radicals to achieve potent anti-aging and anti-cancer actions.

Nucleic Acids: Adenosine and nucleic acids are important physiological factors. Adenosine inhibits platelet aggregation to prevent blood clot formation, atherosclerosis and cardiovascular diseases.

Antrodia Cinnamomea Cultivation

Culturing Antrodia by basswood alone does not guarantee successful Antrodia Cinnamomea growth. It needs to be stimulated via scientific methods, including simulating the natural environment to ensure its ideal cultivation. In addition, further process such as cutting, polishing, drying under the sun, high-pressure cooking, UV sterilization and so forth needs to be observed.

Culturing process:

  1. Spray the mother culture media onto wood chips in the culture room, and apply the chips evenly on the basswood.
  2. Lower the temperature in the culture room so that the mother culture can be absorbed into the basswood that has been processed under high temperature and pressure.
  3. Blow hot air to keep the room warm to expedite the growth of the mother culture media. After 3-6 months, some mycelia will form a yellow layer on the basswood surface.

After 3 years of culturing with the 3 key steps mentioned above, the yellow mycelia will turn red, giving a mature ‘solid body’ that is as good as wild Antrodia Cinnamomea.

1. Antrodia basswood

2. Cutting, polishing, drying under the sun

3. Soaking and high-pressure sterilization

4. Spraying mother culture media

5. Culturing

6. Cinnamomea formation

Product Research and Development

CCT Biotech emphasizes on the importance of research and development to ensure quality, safe and excellent products. Our R&D and Cultivation Center is located in Central Taiwan Science Park (CTSP), Taiwan, where we combine three core functions of R&D, raw material production and quality assurance analysis. In August 2009, the center has passed the strict review and evaluation by the National Science Council (NSC) and six universities. We are also the first company that brings the new “Cultivation Technology” and the new “Efficient Solid-state Culturing Technology” for Antrodia Cinnamomea in Taiwan. In November 2011, the company obtained the ISO22000/HACCP Certification for its international production process.

In addition to our ultra-low temperature (-196˚C) liquid nitrogen storage technology, our strain preservation team also works with academic institutes to identify the activation parameters and the best conditions for preservation. More than 300 strains of Antrodia cinnamomea are kept in the company’s storage bank. Our breeding centers also use mushrooms and fungus to breed more species of bacteria source in order to screen for more active species for future production.

Four Core Technologies And Fungus Identification

Four Core Technologies

1

The preservation, screening and active ingredient upgrading technology of Antrodia cinnamomea

2

The culturing technology of Cinnamomum camphorata for the cultivation of Antrodia cinnamomea

3

The efficient solid-state culturing of Antrodia cinnamomea mycelium

4

The chemical composition detection technology and the biological activity analysis technology

Identification Of Fungus

  1. The strain samples of Antrodia cinnamomea are sent to the following agencies to be identified and safely stored:
  2. Institute of Food Industry Development Corporation – identifies and provides safe storage for the identification report and samples
  3. Institute of Biological Resources and Agronomy Laboratory Management Division of National Taiwan University – provides the identification report
  4. Institute of Microbiology, Chinese Academy of Sciences – identifies the types of bacteria
  5. NCBI GenBank (in affiliation with the National Institutes of Health NIH) – identifies the unique species based on the rDNA of Antrodia cinnamomea
  6. Netherlands Centraalbureau voor Schimmelcultures (CBS) – identifies and provides safe storage for the identification report and samples
  7. The American Type Culture Collection (ATCC) – provides safe storage for samples

Safety Profile Evaluation

To ensure products that are of the desired quality, it is imperative to apply high-end culturing, scientific R&D and production techniques throughout the entire process—from seedling collection to GMP production.

Scientific R&D and production techniques:

1. Selection and cultivation of quality seedlings

2. Good laboratory practices

3. GMP for products

Raw material collection

To ensure materials input are free from pesticides and heavy metal residues

Concentrating the extract

Hi-tech extraction technique, based on Chinese medicinal principles to solidify the bioactive ingredients

Identifying ingredients

Identify and quantify all bioactive ingredients

Analyzing the composition index

Filter and adjust the bioactive ingredients to the correct proportion, as per formula

Efficacy
testing

Ensure the anticipated effects of the health food supplement.

CCT Biotech’s testing protocol are patented for cultivation in many countries and provides a scientific safety profile that has been approved by SGS for product safety and effectiveness. These reports are published in specific health journals.